Long R3 IGF-1 (LONG R3 IGF-I RECOMBINANT ANALOG) is a polypeptide molecule produced by the human endogenous IGF-I gene and is a protein hormone, CAS 143045-27-6. The structure of long R3 IGF-1 is similar to that of human endogenous IGF-I, but 13 additional amino acid residues are added to its N-terminus, so that it has a more persistent and strong biological effect in the body. In vitro tests and clinical practice, long R3 IGF-1 has been widely used in many fields including sports performance improvement, treatment of various diseases, and anti-aging.
1. Improve sports performance:
Long R3 IGF-1 can increase muscle volume and strength, and promote muscle cell proliferation. Using Long R3 IGF-1 during training can increase the rate of muscle growth, allowing for better training results. At the same time, the use of long R3 IGF-1 can increase the body's metabolic rate, thereby improving energy levels and endurance, promoting fat metabolism, reducing body fat content, and better controlling weight. These advantages make long R3 IGF-1 widely used in exercise, sports and other fields.
2. Treatment of growth defects:
Long R3 IGF-1 can be used to treat growth defects in children and adults. This condition is usually caused by missing or insufficient growth hormone. Long R3 IGF-1 can simulate natural growth hormone to promote the secretion of growth hormone in the human body to promote the growth of bones and other tissues.
3. Nerve protection and repair:
Long R3 IGF-1 also contributes to the protection and repair of nerve cells. Long R3 IGF-1 promotes the proliferation and differentiation of nerve cells, improves the survival rate of nerve cells, and helps nerve cells migrate to the damaged area for repair. This function makes long R3 IGF-1 a promising drug for the treatment of neurodegenerative diseases.
4. Strengthen the immune system:
Long R3 IGF-1 also has a stimulating effect on the immune system, so it can be used to improve the body's immunity. Long R3 IGF-1 improves the body's immunity by promoting the expansion of white blood cells and improving their effect. Therefore, long R3 IGF-1 can be used to treat immune system diseases, enhance patient tolerance to diseases such as malignant tumors, and help patients better resist bacterial and viral infections.
5. Anti-aging:
Long R3 IGF-1 helps slow down the body's aging process and promotes increased vitality and energy. By maintaining normal blood sugar levels, maintaining a healthy metabolic rate and tissue function, long R3 IGF-1 can effectively resist the occurrence of aging and degenerative diseases. This function has gradually become one of the important areas for the wide application of long R3 IGF-1 in the medical field.
6. Improved heart function:
Another field of application of long R3 IGF-1 is the improvement of cardiac function. By improving the growth and differentiation of cardiac endothelial cells and cardiomyocytes, as well as the expansion and relaxation of cardiac coronary arteries, long R3 IGF-1 can effectively improve cardiac function and prevent the occurrence of cardiac diseases.
7. Cancer treatment:
Long R3 IGF-1 can be used to treat cancer patients and reduce the burden of late cancer treatment. Long R3 IGF-1 can help cancer patients better cope with the effects of radiotherapy and chemotherapy and increase the sensitivity of cells to radiotherapy and chemotherapy by promoting wound healing, strengthening the immune system and increasing the body's metabolic rate.
In summary, long R3 IGF-1 has broad and important applications in multiple fields, including sports performance enhancement, treatment of growth defects, neuroprotection and repair, immune system enhancement, anti-aging, improvement of cardiac function, and cancer treatment, among others. With the deepening understanding of the biological effects and pharmacology of long R3 IGF-1, its application range and effects will be further expanded and optimized.
According to his variety of uses, we have also carried out research on his other properties. LONG R3 IGF-I is a polypeptide molecule similar in structure to endogenous IGF-I, with 13 additional amino acids, which has very important biological and pharmaceutical significance.
1. Molecular structure:
Long R3 IGF-I consists of 70 amino acid residues, the first three of which are arabinose (Ala-Pro-Ala), which have typical structural characteristics of proteins and polypeptides. Long R3 IGF-I has an additional 13 amino acid sequences added to the N-terminus, so that the difference from endogenous IGF-I mainly lies in the changes in its molecular size and structure. Long R3 IGF-I has a molecular weight of approximately 9 kDa, has an -helical structure and four disulfide bonds, and a soluble C-terminal domain and an extracellular domain.
2. Electrochemical properties:
LONG R3 IGF-I is a charged polypeptide molecule with a net charge usually plus 2 or plus 3. Its specific electrochemical properties depend on its pH value, buffer, ionic strength and other factors. Under the condition of pH 7.4, the isoelectric point of LONG R3 IGF-I is about 8.6, and it has high electrophoretic mobility. Its ionization properties have an important impact on its solubility, biological activity and application in drug delivery.
3. Solubility:
LONG R3 IGF-I is a hydrophilic polypeptide molecule, which is easy to dissolve in water and forms a stable aqueous phase solution. In common buffers, such as phosphate buffer, PBS buffer, etc., the solubility and stability of LONG R3 IGF-I are very good. However, in some extreme conditions, such as low pH, high temperature, high salinity and other conditions, the solubility and stability of LONG R3 IGF-I will be affected.
4. Stability:
The stability of long R3 IGF-I depends on its storage and use conditions, such as storage temperature, buffer pH, salt concentration, freeze-thaw times and other factors. Normally, the stability of long R3 IGF-I will be guaranteed below -20 degree or in a lyophilized state. During use, LONG R3 IGF-I needs to avoid prolonged exposure to air to avoid protein denaturation or peroxide formation. In addition, long R3 IGF-I also needs to pay attention to the contact and interaction with metal ions, organic solvents and other factors that may affect its stability.
5. Adsorption:
Long R3 IGF-I has a certain degree of adsorption and can be adsorbed by a variety of adsorption materials, including ion exchange resins, gel filtration materials, affinity chromatography, etc. The separation and purification efficiency and purity of LONG R3 IGF-I can be effectively improved when the adsorption material selection and operating conditions are correct.
6. Surface activity:
Long R3 IGF-I has certain surface activity, which can affect its dissociation and folding state, thereby affecting its structure and function. Under certain conditions, such as high concentration, low pH, etc., the surface activity of long R3 IGF-I is strong, and adverse reactions such as aggregation may occur. Therefore, during use, its dissociation behavior and the pH of the buffer need to be carefully controlled to ensure its stability and biological activity.
In summary, the physical properties of LONG R3 IGF-I have a very important influence and significance for its pharmaceutical and biological applications. For the different applications of LONG R3 IGF-I, it is necessary to carefully control its physical properties and select appropriate operating conditions and methods to achieve the best effect and application value.