6-methylergoline-8beta-carboxylic Acid is an organic compound with a chemical formula of C18H19N3O2 and a relative molecular mass of 313.4 g/mol. It is a white solid powder, not easily soluble in water, but easily soluble in ethanol and dimethyl sulfoxide. Is a psilocybin (serotonin) receptor agonist. This compound is a synthetic molecule that is often used in research in the medical field.
The binding of 6-Me-Erg-8 to actin has a certain affinity and can be used to treat related diseases. For example, the compound can be used to treat neurological diseases such as Parkinson's disease, Alzheimer's disease and vascular dementia. In addition, 6-Me-Erg-8 is also widely used in academia to explore its effects on cell growth, cell proliferation, and cancer treatment.
In conclusion, 6-methylergoline-8beta-carboxylic Acid has very important research value in medicine and bioscience, and has been widely used in related fields.
Its chemical properties have the following aspects:
Acidity: This compound is an organic acid that can produce reactions such as salt and hydrochloric acid.
Redox: 6-methylergoline-8beta-carboxylic acid can react with certain redox agents, for example, it can be oxidized to 6-methylergoline-8beta-carboxamide by hydrogen peroxide.
Other reactions: This compound has certain stability, but it is prone to degradation and decomposition reactions under conditions such as light, humidity, and high temperature.
chemical reaction:
1. Esterification reaction: 6-methylergoline-8beta-carboxylic Acid can react with alcohols to form esters.
2. Carboxylation reaction: This compound can react with NaNO2 to generate the corresponding nitroso compound.
3. Cleavage reaction: This compound is prone to cleavage reaction under strong acid and strong alkali conditions.
4. Reduction reaction: 6-methylergoline-8beta-carboxylic Acid can reduce carboxyl group to alcohol group through reduction reaction.
6-methylergoline-8beta-carboxylic acid is an important bioactive molecule with a wide range of uses. Two synthetic routes and detailed steps about it will be introduced below.
Synthetic route 1:
Synthetic route 1 is based on Lysergic acid as the starting material. The detailed steps are as follows:
Step 1: Synthesis of lysergic acid diethylamide (LSD): Lysergic acid and Diethylamine undergo amidation reaction to obtain LSD.
Step 2: Restore LSD through catalytic hydrogenation to obtain Lysergic acid.
Step 3: Lysergic acid undergoes decarboxylation to prepare the preferred intermediate: 1,2,3,4-tetrahydro-6-methylergoline.
Step 4: Further oxidation and hydroxymethylation reaction to obtain the final product: 6-methylergoline-8beta-carboxylic Acid.
Synthetic route 2:
Synthetic route 2 is based on Indole-3-acetaldehyde as the starting material. Its main steps are as follows:
Step 1: React Indole-3-acetaldehyde with dimethylamine to obtain DMIA.
Step 2: React DMIA with Acrylic acid to obtain a compound with Diene structure.
Step 3: The indolic beta-carbolines structure as a mixture of diastereomers is obtained by addition reaction of Diene compound by Baker-Reynolds method.
Step 4: Active intermediates are produced during the conversion reaction, and the active intermediates are converted into 6-methylergoline-8beta-carboxylic Acid through special reaction conditions.
The above are the two synthetic routes and detailed steps of 6-methylergoline-8beta-carboxylic Acid. These two routes have their own advantages and disadvantages, and researchers can choose the most suitable route according to their needs in order to prepare compounds with high purity and high yield.
6-methylergoline-8beta-carboxylic Acid is a synthetic alkaloid, also known as Mecarboxaldehyde or 6-MBA. It is made from lysergic acid through a series of chemical reactions and has a molecular structure similar to lysergic acid. The compound has wide application prospects in pharmacy and agriculture, and has very good development potential.
In medicine, 6-methylergoline-8beta-carboxylic Acid has many potential curative effects. The compound can be used to treat Parkinson's disease, rheumatoid arthritis, colitis, multiple sclerosis, epilepsy and other diseases. Particularly in the treatment of Parkinson's disease, the compound could be a novel treatment because it acts as an agonist of dopamine receptors to increase dopamine levels and help relieve symptoms.
In agriculture, 6-methylergoline-8beta-carboxylic Acid also has certain application prospects. As a new type of insecticide, it can be used to protect crops. The compound has excellent insecticidal activity and has obvious killing effects on various pests. Therefore, the application potential in the field of agriculture is also very broad.
Historically, 6-methylergoline-8beta-carboxylic acid has been overlooked due to some potential side effects. But with the development of science and technology, people gradually found that this compound has broad application prospects. In the future, 6-methylergoline-8beta-carboxylic acid is expected to become a new type of drug and insecticide, contributing to human health and food security.